Drug Information

Drug General Information
Drug ID
D0V4PL
Former ID
DNC008335
Drug Name
3-(3,3-dimethyl-2-oxoindolin-5-yl)benzonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529352]
Structure
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2D MOL

3D MOL
Formula
C17H14N2O
Canonical SMILES
CC1(C2=C(C=CC(=C2)C3=CC=CC(=C3)C#N)NC1=O)C
InChI
1S/C17H14N2O/c1-17(2)14-9-13(6-7-15(14)19-16(17)20)12-5-3-4-11(8-12)10-18/h3-9H,1-2H3,(H,19,20)
InChIKey
WZZPSUKZMZKXTQ-UHFFFAOYSA-N
PubChem Compound ID
9903358
Target and Pathway
Target(s) Progesterone receptor Target Info Inhibitor [529352]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturation
Pathway Interaction Database Cellular roles of Anthrax toxin
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear Receptors
References
Ref 529352J Med Chem. 2008 Mar 27;51(6):1861-73. Epub 2008 Mar 5.Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).
Ref 529352J Med Chem. 2008 Mar 27;51(6):1861-73. Epub 2008 Mar 5.Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).

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