Drug Information

Drug General Information
Drug ID
D0TL3N
Former ID
DNC009961
Drug Name
5-(biphenyl-4-yl)-3-methoxypentanoic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530333]
Structure
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2D MOL

3D MOL
Formula
C18H20O3
Canonical SMILES
COC(CCC1=CC=C(C=C1)C2=CC=CC=C2)CC(=O)O
InChI
1S/C18H20O3/c1-21-17(13-18(19)20)12-9-14-7-10-16(11-8-14)15-5-3-2-4-6-15/h2-8,10-11,17H,9,12-13H2,1H3,(H,19,20)
InChIKey
KYPWLTXIHUQMGA-UHFFFAOYSA-N
PubChem Compound ID
45482998
Target and Pathway
Target(s) MMP-12 Target Info Inhibitor [530333]
NetPath Pathway IL1 Signaling Pathway
IL5 Signaling Pathway
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
WikiPathways TGF beta Signaling Pathway
Degradation of collagen
Matrix Metalloproteinases
References
Ref 530333Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. Epub 2009 Aug 6.The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.
Ref 530333Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. Epub 2009 Aug 6.The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.

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