Drug General Information
Drug ID	D00QDR
Former ID	DNC008869
Drug Name	1,2,3,4,6-penta-O-galloyl-beta-D-glucose
Synonyms	Pentagalloyl glucose; Penta-O-galloyl-beta-glucoside
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534762]
Structure		Download 2D MOL 3D MOL
Formula	C41H32O26
PubChem Compound ID	65238
Target and Pathway
Target(s)	Coagulation factor Xa	Target Info	Inhibitor	[534762]
	Squalene monooxygenase	Target Info	Inhibitor	[526128]
	Xanthine dehydrogenase/oxidase	Target Info	Inhibitor	[551350]
	Coagulation factor IIa	Target Info	Inhibitor	[534762]
BioCyc Pathway	Purine nucleotides degradation
	Urate biosynthesis/inosine 5'-phosphate degradation
	Guanosine nucleotides degradation
	Adenosine nucleotides degradation
	Retinoate biosynthesis II
KEGG Pathway	Complement and coagulation cascadessce00100:Steroid biosynthesis
	Sesquiterpenoid and triterpenoid biosynthesis
	Metabolic pathways
	Biosynthesis of secondary metabolites
	Biosynthesis of antibioticshsa00230:Purine metabolism
	Caffeine metabolism
	Drug metabolism - other enzymes
	Metabolic pathways
	Peroxisomehsa04080:Neuroactive ligand-receptor interaction
	Complement and coagulation cascades
	Regulation of actin cytoskeleton
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Blood coagulationP02723:Adenine and hypoxanthine salvage pathway
	Purine metabolismP00011:Blood coagulation
Pathway Interaction Database	Beta2 integrin cell surface interactionsthrombin_pathway:Thrombin/protease-activated receptor (PAR) pathway
	Angiopoietin receptor Tie2-mediated signaling
	FOXA2 and FOXA3 transcription factor networks
	PAR4-mediated thrombin signaling events
	Syndecan-4-mediated signaling events
	PAR1-mediated thrombin signaling events
PathWhiz Pathway	CoagulationPW000050:Steroid BiosynthesisPW000015:Caffeine Metabolism
	Purine MetabolismPW000047:Vitamin K Metabolism
	Coagulation
Reactome	Extrinsic Pathway of Fibrin Clot Formation
	Intrinsic Pathway of Fibrin Clot Formation
	Common Pathway of Fibrin Clot Formation
	Gamma-carboxylation of protein precursors
	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
	Removal of aminoterminal propeptides from gamma-carboxylated proteinsR-HSA-191273:Cholesterol biosynthesis
	Activation of gene expression by SREBF (SREBP)R-HSA-74259:Purine catabolismR-HSA-140837:Intrinsic Pathway of Fibrin Clot Formation
	Removal of aminoterminal propeptides from gamma-carboxylated proteins
	Cell surface interactions at the vascular wall
	Peptide ligand-binding receptors
	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	G alpha (q) signalling events
	Thrombin signalling through proteinase activated receptors (PARs)
WikiPathways	Complement and Coagulation Cascades
	Human Complement System
	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
	Blood Clotting Cascade
	Formation of Fibrin Clot (Clotting Cascade)WP408:Oxidative Stress
	Effects of Nitric Oxide
	Metabolism of nucleotides
	Selenium Micronutrient NetworkWP558:Complement and Coagulation Cascades
	Regulation of Actin Cytoskeleton
	IL1 and megakaryotyces in obesity
	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	Gastrin-CREB signalling pathway via PKC and MAPK
	Thrombin signalling through proteinase activated receptors (PARs)
	Platelet Aggregation (Plug Formation)
	GPCR ligand binding
	GPCR downstream signaling
	Formation of Fibrin Clot (Clotting Cascade)
	Cell surface interactions at the vascular wall
	Folate Metabolism
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
References
Ref 534762	J Nat Prod. 1998 Nov;61(11):1356-60.Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade.
Ref 526128	J Nat Prod. 2001 Aug;64(8):1010-4.Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase.
Ref 534762	J Nat Prod. 1998 Nov;61(11):1356-60.Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade.
Ref 551350	Pentagalloylglucose, a xanthine oxidase inhibitor from a Paraguayan crude drug, "Molle-i" (Schinus terebinthifolius). J Nat Prod. 1989 Jan-Feb;52(1):210-1.

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