Drug Information

Drug General Information
Drug ID
D0Y7QY
Former ID
DNC005613
Drug Name
(E)-3-(4-tert-Butyl-phenyl)-N-phenyl-acrylamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527363]
Structure
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2D MOL

3D MOL
Formula
C19H21NO
Canonical SMILES
CC(C)(C)C1=CC=C(C=C1)C=CC(=O)NC2=CC=CC=C2
InChI
1S/C19H21NO/c1-19(2,3)16-12-9-15(10-13-16)11-14-18(21)20-17-7-5-4-6-8-17/h4-14H,1-3H3,(H,20,21)/b14-11+
InChIKey
AVMIAJAOFXDOSN-SDNWHVSQSA-N
PubChem Compound ID
5885566
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Inhibitor [527363]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 527363J Med Chem. 2005 Jan 13;48(1):71-90.Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides.
Ref 527363J Med Chem. 2005 Jan 13;48(1):71-90.Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides.

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