TTD | Drug: D05DBJ

Drug General Information
Drug ID	D05DBJ
Former ID	DNC009410
Drug Name	2-(4-methoxybenzylthio)-6-methylpyrimidin-4-ol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529392]
Structure		Download 2D MOL 3D MOL
Formula	C13H14N2O2S
Canonical SMILES	CC1=CC(=O)N=C(N1)SCC2=CC=C(C=C2)OC
InChI	1S/C13H14N2O2S/c1-9-7-12(16)15-13(14-9)18-8-10-3-5-11(17-2)6-4-10/h3-7H,8H2,1-2H3,(H,14,15,16)
InChIKey	XMFWHLZTTUUQHL-UHFFFAOYSA-N
PubChem Compound ID	716696
Target and Pathway
Target(s)	Collagenase 3	Target Info	Inhibitor	[529392]
NetPath Pathway	IL1 Signaling Pathway
PANTHER Pathway	Alzheimer disease-presenilin pathway
PANTHER Pathway	Plasminogen activating cascade
Pathway Interaction Database	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
	Assembly of collagen fibrils and other multimeric structures
WikiPathways	Endochondral Ossification
	Activation of Matrix Metalloproteinases
	Oncostatin M Signaling Pathway
	AGE/RAGE pathway
	Matrix Metalloproteinases
References
Ref 529392	Bioorg Med Chem. 2009 Feb 1;17(3):1101-8. Epub 2008 Mar 8.Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study.
Ref 529392	Bioorg Med Chem. 2009 Feb 1;17(3):1101-8. Epub 2008 Mar 8.Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study.

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Drug Information