Drug General Information
Drug ID	D0B7ZB
Former ID	DNC007917
Drug Name	4-(4-isopropylphenyl)-5-cyano-2H-1,2,3-triazole
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528580]
Structure		Download 2D MOL 3D MOL
Formula	C12H12N4
Canonical SMILES	CC(C)C1=CC=C(C=C1)C2=NNN=C2C#N
InChI	1S/C12H12N4/c1-8(2)9-3-5-10(6-4-9)12-11(7-13)14-16-15-12/h3-6,8H,1-2H3,(H,14,15,16)
InChIKey	WEMPWGDVLUDOBY-UHFFFAOYSA-N
PubChem Compound ID	44437844
Target and Pathway
Target(s)	mRNA of HER2	Target Info	Inhibitor	[528580]
KEGG Pathway	ErbB signaling pathway
	Calcium signaling pathway
	HIF-1 signaling pathway
	Focal adhesion
	Adherens junction
	Pathways in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
	Pancreatic cancer
	Endometrial cancer
	Prostate cancer
	Bladder cancer
	Non-small cell lung cancer
	Central carbon metabolism in cancer
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Cadherin signaling pathway
	EGF receptor signaling pathway
Pathway Interaction Database	ErbB4 signaling events
	ErbB2/ErbB3 signaling events
	ErbB receptor signaling network
	a6b1 and a6b4 Integrin signaling
	Validated targets of C-MYC transcriptional repression
PathWhiz Pathway	Phosphatidylinositol Phosphate Metabolism
Reactome	SHC1 events in ERBB2 signaling
	PLCG1 events in ERBB2 signaling
	PIP3 activates AKT signaling
	GRB2 events in ERBB2 signaling
	PI3K events in ERBB2 signaling
	Constitutive Signaling by Aberrant PI3K in Cancer
	Sema4D induced cell migration and growth-cone collapse
	RAF/MAP kinase cascade
WikiPathways	DNA Damage Response (only ATM dependent)
	ErbB Signaling Pathway
	EGF/EGFR Signaling Pathway
	Extracellular vesicle-mediated signaling in recipient cells
	Bladder Cancer
	Signaling by ERBB2
	Integrated Pancreatic Cancer Pathway
	Signaling Pathways in Glioblastoma
	Leptin signaling pathway
	miR-targeted genes in muscle cell - TarBase
	Semaphorin interactions
References
Ref 528580	Bioorg Med Chem. 2007 Feb 1;15(3):1533-8. Epub 2006 Dec 15.Synthesis and biological evaluation of 4-aryl-5-cyano-2H-1,2,3-triazoles as inhibitor of HER2 tyrosine kinase.
Ref 528580	Bioorg Med Chem. 2007 Feb 1;15(3):1533-8. Epub 2006 Dec 15.Synthesis and biological evaluation of 4-aryl-5-cyano-2H-1,2,3-triazoles as inhibitor of HER2 tyrosine kinase.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.