Drug Information

Drug General Information
Drug ID
D08KVZ
Former ID
DAP000176
Drug Name
Sibutramine
Synonyms
Butramin; Medaria; Meridia; Reductil; Sibutramina; Sibutraminum; Sibutramina [Spanish]; Sibutraminum [Latin]; BTS-54524; Butramin (TN); Ectiva (TN); Meridia (TN); Reductil (TN); Sibutramine (INN); Sibutramine [INN:BAN]; N-1-(1-(4-chlorophenyl)cyclobutyl)-3-methylbutyl-N,N-dimethylamine HCl; 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Approved [536710], [539665]
Therapeutic Class
Appetite Depressants
Company
Abbott Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C17H26ClN
InChI
InChI=1S/C17H26ClN/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14/h6-9,13,16H,5,10-12H2,1-4H3
InChIKey
UNAANXDKBXWMLN-UHFFFAOYSA-N
CAS Number
CAS 106650-56-0
PubChem Compound ID
5210
PubChem Substance ID
9456, 3206268, 4368412, 7980597, 8153202, 11364918, 11367480, 11370042, 11372056, 11374791, 11378212, 11485348, 11489502, 11490824, 11492951, 11495775, 14750864, 29224267, 46387014, 46507740, 47509538, 47805058, 48416537, 49732001, 49816816, 49830262, 50064120, 50105677, 50474598, 57322655, 81040718, 85279508, 92308675, 92309273, 92714514, 93625048, 96025198, 103498411, 104308577, 108667174, 118048829, 121147434, 124659142, 124813324, 125311920, 125325628, 125337324, 126629463, 126655363, 126682940
SuperDrug ATC ID
A08AA10
SuperDrug CAS ID
cas=106650560
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Modulator [556264]
Sodium-dependent serotonin transporter Target Info Modulator [556264]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Adrenaline and noradrenaline biosynthesisP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
SIDS Susceptibility Pathways
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 536710Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50.
Ref 539665(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2586).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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