Drug Information

Drug General Information
Drug ID
D03BPG
Former ID
DIB021006
Drug Name
T0070907
Synonyms
T 0070907
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540384]
Structure
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2D MOL

3D MOL
Formula
C12H8ClN3O3
InChI
InChI=1S/C12H8ClN3O3/c13-11-2-1-9(16(18)19)7-10(11)12(17)15-8-3-5-14-6-4-8/h1-7H,(H,14,15,17)
InChIKey
FRPJSHKMZHWJBE-UHFFFAOYSA-N
PubChem Compound ID
2777391
PubChem Substance ID
3214033, 4732069, 8311198, 14942325, 26753272, 26759597, 39873915, 47621310, 53790303, 53800506, 57409931, 58107069, 74775583, 85788697, 88806321, 103019199, 103630155, 104113777, 104707086, 111395727, 121361645, 125333843, 125382174, 134346899, 135302778, 135697953, 136378423, 137000582, 137166932, 140219697, 152212820, 152258459, 160647295, 160814756, 162009759, 162023266, 162068615, 162130473, 162192853, 162945942, 163564804, 163687258, 164194064, 174474524, 174560767, 175612579, 178100444, 180056909, 184583104, 184813549
Target and Pathway
Target(s) mRNA of PPAR-gamma Target Info Antagonist [526285]
KEGG Pathway PPAR signaling pathway
AMPK signaling pathway
Osteoclast differentiation
Huntington's disease
Pathways in cancer
Transcriptional misregulation in cancer
Thyroid cancer
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway CCKR signaling map ST
Pathway Interaction Database Noncanonical Wnt signaling pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by HDAC Class I
RXR and RAR heterodimerization with other nuclear receptor
Regulation of retinoblastoma protein
Reactome PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
WikiPathways Wnt Signaling Pathway Netpath
Nuclear Receptors in Lipid Metabolism and Toxicity
Differentiation of white and brown adipocyte
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional Regulation of White Adipocyte Differentiation
Adipogenesis
SREBP signalling
Nuclear Receptors
References
Ref 540384(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3444).
Ref 526285T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. J Biol Chem. 2002 May 31;277(22):19649-57. Epub 2002 Mar 4.

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