Drug General Information
Drug ID	D0Q2LL
Former ID	DNC004479
Drug Name	6-Hydroxy-benzothiazole-2-sulfonic acid amide
Synonyms	6-hydroxybenzo[d]thiazole-2-sulfonamide
Indication	Discovery agent		Investigative	[529948]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Carbonic anhydrase I	Target Info	Inhibitor	[529948]
	Carbonic anhydrase	Target Info	Inhibitor	[529948]
	Carbonic anhydrase XII	Target Info	Inhibitor	[527407]
	Carbonic anhydrase II	Target Info	Inhibitor	[529948]
	Carbonic anhydrase XIV	Target Info	Inhibitor	[527654]
	Carbonic anhydrase VI	Target Info	Inhibitor	[529948]
	Carbonic anhydrase IX	Target Info	Inhibitor	[529948]
KEGG Pathway	Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
	Proximal tubule bicarbonate reclamation
	Collecting duct acid secretion
	Gastric acid secretion
	Pancreatic secretion
	Bile secretionhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
NetPath Pathway	TGF_beta_Receptor Signaling PathwayNetPath_16:IL4 Signaling Pathway
	EGFR1 Signaling Pathway
Pathway Interaction Database	C-MYB transcription factor networkhif1_tfpathway:HIF-1-alpha transcription factor network
PathWhiz Pathway	Gastric Acid Production
Reactome	Erythrocytes take up carbon dioxide and release oxygen
	Erythrocytes take up oxygen and release carbon dioxide
	Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
	Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
	Reversible hydration of carbon dioxide
WikiPathways	Reversible Hydration of Carbon Dioxide
	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
	Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide
	Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon DioxideWP2877:Vitamin D Receptor Pathway
	Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
References
Ref 529948	J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Ref 527407	Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9.Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?.
Ref 527654	Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33.Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.
Ref 529948	J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.

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