Drug General Information
Drug ID	D04KCX
Former ID	DNC014391
Drug Name	5-(4-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530900]
Structure		Download 2D MOL 3D MOL
Formula	C8H6N2O2S
Canonical SMILES	C1=CC(=O)C=CC1=C2NNC(=S)O2
InChI	1S/C8H6N2O2S/c11-6-3-1-5(2-4-6)7-9-10-8(13)12-7/h1-4,9H,(H,10,13)
InChIKey	SUVWGKRXUGXUMP-UHFFFAOYSA-N
PubChem Compound ID	5385959
Target and Pathway
Target(s)	Tyrosine oxidase	Target Info	Inhibitor	[530900]
BioCyc Pathway	(S)-reticuline biosynthesis
	Eumelanin biosynthesis
	L-dopachrome biosynthesis
KEGG Pathway	Tyrosine metabolism
	Riboflavin metabolism
	Metabolic pathways
	Melanogenesis
PathWhiz Pathway	Riboflavin Metabolism
	Tyrosine Metabolism
WikiPathways	Dopamine metabolism
References
Ref 530900	Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. Epub 2010 Apr 13.New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.
Ref 530900	Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. Epub 2010 Apr 13.New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.

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