Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0L4FM
|
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| Former ID |
DNC005929
|
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| Drug Name |
PHENYLSULFAMATE
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [527782] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C6H7NO3S
|
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| Canonical SMILES |
C1=CC=C(C=C1)OS(=O)(=O)N
|
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| InChI |
1S/C6H7NO3S/c7-11(8,9)10-6-4-2-1-3-5-6/h1-5H,(H2,7,8,9)
|
||||
| InChIKey |
XOIYZMDJFLKIEI-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Carbonic anhydrase II | Target Info | Inhibitor | [528233] | |
| Carbonic anhydrase IX | Target Info | Inhibitor | [527782] | ||
| Carbonic anhydrase I | Target Info | Inhibitor | [527782] | ||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| EGFR1 Signaling Pathway | |||||
| Pathway Interaction Database | HIF-1-alpha transcription factor networkcmyb_pathway:C-MYB transcription factor network | ||||
| PathWhiz Pathway | Gastric Acid Production | ||||
| Reactome | Erythrocytes take up carbon dioxide and release oxygen | ||||
| Erythrocytes take up oxygen and release carbon dioxide | |||||
| Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor | |||||
| Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen | |||||
| Reversible hydration of carbon dioxide | |||||
| WikiPathways | Reversible Hydration of Carbon Dioxide | ||||
| Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | |||||
| Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2877:Vitamin D Receptor Pathway | |||||
| Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide | |||||
| Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes | |||||
| References | |||||
| Ref 527782 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. | ||||
| Ref 528233 | J Med Chem. 2006 Jun 15;49(12):3496-500.Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements. | ||||
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