Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03BRM
|
||||
| Former ID |
DIB018916
|
||||
| Drug Name |
AUY954
|
||||
| Synonyms |
AUY 954
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Discovery agent | Investigative | [539942] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C25H20F3NO2S
|
||||
| InChI |
InChI=1S/C25H20F3NO2S/c26-25(27,28)21-13-18(7-8-20(21)17-4-2-1-3-5-17)23-14-19-12-16(6-9-22(19)32-23)15-29-11-10-24(30)31/h1-9,12-14,29H,10-11,15H2,(H,30,31)
|
||||
| InChIKey |
SKYYWSWIUKISCX-UHFFFAOYSA-N
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | S1P4 receptor | Target Info | Agonist | [528529] | |
| Sphingosine 1-phosphate receptor 1 | Target Info | Agonist | [528529] | ||
| Sphingosine 1-phosphate receptor 5 | Target Info | Agonist | [528529] | ||
| Sphingosine-1-phosphate receptor-2 | Target Info | Agonist | [528529] | ||
| Sphingosine-1-phosphate receptor-3 | Target Info | Agonist | [528528] | ||
| Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | ||||
| S1P3 pathway | |||||
| S1P1 pathway | |||||
| Sphingosine 1-phosphate (S1P) pathway | |||||
| PDGFR-beta signaling pathways1p_s1p4_pathway:S1P4 pathway | |||||
| S1P5 pathway | |||||
| Sphingosine 1-phosphate (S1P) pathways1p_s1p3_pathway:S1P3 pathway | |||||
| S1P2 pathways1p_s1p3_pathway:S1P3 pathway | |||||
| References | |||||
| Ref 528528 | Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorg Med Chem. 2007 Jan 15;15(2):663-77. Epub2006 Nov 1. | ||||
| Ref 528529 | A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol. 2006 Nov;13(11):1227-34. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.