Drug Information

Drug General Information
Drug ID
D0QE3C
Former ID
DNC013476
Drug Name
2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529241]
Structure
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2D MOL

3D MOL
Formula
C17H13NO
Canonical SMILES
C1CC2=C(C=CC(=N2)C#CC3=CC=CC=C3)C(=O)C1
InChI
1S/C17H13NO/c19-17-8-4-7-16-15(17)12-11-14(18-16)10-9-13-5-2-1-3-6-13/h1-3,5-6,11-12H,4,7-8H2
InChIKey
XOUDFZJCSDKXLG-UHFFFAOYSA-N
PubChem Compound ID
11379626
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [529241]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 529241J Med Chem. 2008 Feb 14;51(3):634-47. Epub 2008 Jan 4.Positive and negative modulation of group I metabotropic glutamate receptors.
Ref 529241J Med Chem. 2008 Feb 14;51(3):634-47. Epub 2008 Jan 4.Positive and negative modulation of group I metabotropic glutamate receptors.

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