Drug Information
Drug General Information | |||||
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Drug ID |
D07HQZ
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Former ID |
DIB018321
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Drug Name |
[3H]LSD
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Synonyms |
[3H]N,N-diethyllysergamide; [3H]lysergic acid diethylamide; [3H]lysergide
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [539390] | ||
Structure |
Download2D MOL |
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Formula |
C20H25N3O
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InChI |
InChI=1S/C20H25N3O/c1-4-23(5-2)20(24)14-9-16-15-7-6-8-17-19(15)13(11-21-17)10-18(16)22(3)12-14/h6-9,11,14,18,21H,4-5,10,12H2,1-3H3/t14-,18-/m1/s1/i3T3
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InChIKey |
VAYOSLLFUXYJDT-QZGBZKRISA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | 5-hydroxytryptamine 7 receptor | Target Info | Agonist | [534474] | |
5-hydroxytryptamine 2B receptor | Target Info | Agonist | [526621] | ||
5-hydroxytryptamine 6 receptor | Target Info | Agonist | [525492] | ||
5-hydroxytryptamine 2C receptor | Target Info | Agonist | [543963] | ||
KEGG Pathway | Ras signaling pathway | ||||
Calcium signaling pathway | |||||
Neuroactive ligand-receptor interaction | |||||
Serotonergic synapsehsa04020:Calcium signaling pathway | |||||
Gap junction | |||||
Serotonergic synapse | |||||
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway | |||||
cAMP signaling pathway | |||||
Inflammatory mediator regulation of TRP channels | |||||
WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
Monoamine GPCRs | |||||
GPCRs, Class A Rhodopsin-like | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling | |||||
GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
References | |||||
Ref 525492 | Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes. Neuropsychopharmacology. 1999 Jun;20(6):612-27. | ||||
Ref 526621 | Identification of the binding sites and selectivity of sarpogrelate, a novel 5-HT2 antagonist, to human 5-HT2A, 5-HT2B and 5-HT2C receptor subtypes by molecular modeling. Life Sci. 2003 May 30;73(2):193-207. | ||||
Ref 534474 | Human serotonin 5-HT7 receptor: cloning and pharmacological characterisation of two receptor variants. FEBS Lett. 1997 Aug 25;413(3):489-94. | ||||
Ref 543963 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 8). |
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