Drug Information

Drug General Information
Drug ID
D05ZHQ
Former ID
DIB019807
Drug Name
EHNA
Synonyms
erythro-9-(2-hydroxy-3-nonyl)adenine hydrochloride
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468240]
Structure
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2D MOL

3D MOL
Formula
C14H24ClN5O
InChI
InChI=1S/C14H23N5O.ClH/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19;/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17);1H/t10-,11+;/m1./s1
InChIKey
VVDXNJRUNJMYOZ-DHXVBOOMSA-N
PubChem Compound ID
11056106
PubChem Substance ID
16122904, 23270082, 80429108, 178101869
Target and Pathway
Target(s) CGMP-dependent3',5'-cyclic phosphodiesterase Target Info Inhibitor [534171]
Adenosine deaminase Target Info Inhibitor [534055]
BioCyc Pathway Purine nucleotides degradation
Purine deoxyribonucleosides degradation
Purine ribonucleosides degradation to ribose-1-phosphate
Adenosine nucleotides degradation
Superpathway of purine nucleotide salvage
Adenine and adenosine salvage III
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
Morphine addictionhsa00230:Purine metabolism
Metabolic pathways
Primary immunodeficiency
NetPath Pathway TSH Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Adenine and hypoxanthine salvage pathway
Pathway Interaction Database p73 transcription factor network
C-MYB transcription factor network
Validated transcriptional targets of deltaNp63 isoforms
Validated transcriptional targets of TAp63 isoforms
PathWhiz Pathway Purine Metabolism
Reactome cGMP effects
G alpha (s) signalling eventsR-HSA-74217:Purine salvage
WikiPathways Metabolism of nucleotides
References
Ref 468240(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5179).
Ref 534055Tight-binding inhibitors--IV. Inhibition of adenosine deaminases by various inhibitors. Biochem Pharmacol. 1977 Mar 1;26(5):359-67.
Ref 534171Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram. Cell Signal. 1996 Feb;8(2):97-110.

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