Drug Information

Drug General Information
Drug ID
D0LB0X
Former ID
DIB018009
Drug Name
KH064
Synonyms
sPLA2-2A inhibitor, compound 2b
Drug Type
Small molecular drug
Indication Breast cancer [ICD9: 174, 175; ICD10:C50] Clinical trial [526563]
Structure
Download
2D MOL
Formula
C31H37NO4
InChI
InChI=1S/C31H37NO4/c33-30(16-10-2-1-5-11-25-12-6-3-7-13-25)32-28(19-22-31(34)35)23-26-17-20-29(21-18-26)36-24-27-14-8-4-9-15-27/h3-4,6-9,12-15,17-18,20-21,28H,1-2,5,10-11,16,19,22-24H2,(H,32,33)(H,34,35)/t28-/m0/s1
InChIKey
KWLUIYFCMHKLKY-NDEPHWFRSA-N
PubChem Compound ID
446400
PubChem Substance ID
7886202, 10299889, 24724605, 36888834, 46392256, 50581597, 96099862, 103756914, 104636435, 125259319, 136350303, 137255086, 144241622, 160649705, 162247981, 170485752, 178103314, 208012488, 208265199, 223852693, 230253822, 246961284
Target and Pathway
Target(s) Phospholipase A2, membrane associated Target Info Inhibitor [526563]
BioCyc Pathway Phospholipases
KEGG Pathway Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Metabolic pathways
Ras signaling pathway
Vascular smooth muscle contraction
Pancreatic secretion
Fat digestion and absorption
Pathway Interaction Database Glypican 1 network
Reactome Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PI
WikiPathways Cardiac Hypertrophic Response
Glycerophospholipid biosynthesis
Glycerophospholipid Biosynthetic Pathway
Spinal Cord Injury
Eicosanoid Synthesis
MicroRNAs in cardiomyocyte hypertrophy
References
Ref 526563D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity. Chembiochem. 2003 Mar 3;4(2-3):181-5.
Ref 526563D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity. Chembiochem. 2003 Mar 3;4(2-3):181-5.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.