Drug Information

Drug General Information
Drug ID
D08TBP
Former ID
DNC005162
Drug Name
2-Acetylamino-indan-5-sulfonic acid hydrate
Indication Discovery agent Investigative [527262]
Structure
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2D MOL

3D MOL
Canonical SMILES
CC(=O)NC1CC2=C(C1)C=C(C=C2)S(=O)(=O)O.O
InChI
1S/C11H13NO4S.H2O/c1-7(13)12-10-4-8-2-3-11(17(14,15)16)6-9(8)5-10;/h2-3,6,10H,4-5H2,1H3,(H,12,13)(H,14,15,16);1H2
InChIKey
QPSIRRUMXKUUFC-UHFFFAOYSA-N
Target and Pathway
Target(s) Carbonic anhydrase II Target Info Inhibitor [527262]
Carbonic anhydrase I Target Info Inhibitor [527262]
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretionhsa00910:Nitrogen metabolism
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Gastric Acid Production
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 527262Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6.Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties.
Ref 527262Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6.Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties.

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