Target Information
Target General Infomation | |||||
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Target ID |
T99912
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Former ID |
TTDR00950
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Target Name |
Kynureninase
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Gene Name |
KYNU
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Synonyms |
L-kynurenine hydrolase; KYNU
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Target Type |
Research
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Function |
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
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BioChemical Class |
Carbon-carbon bonds hydrolase
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UniProt ID | |||||
EC Number |
EC 3.7.1.3
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Sequence |
MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLS
LVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLM KDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHG LNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAG QAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKP ALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKK SVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEK RGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN |
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Pathways | |||||
BioCyc Pathway | Superpathway of tryptophan utilization | ||||
Tryptophan degradation | |||||
L-kynurenine degradation | |||||
Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde | |||||
NAD de novo biosynthesis | |||||
KEGG Pathway | Tryptophan metabolism | ||||
Metabolic pathways | |||||
NetPath Pathway | TSLP Signaling Pathway | ||||
PathWhiz Pathway | Tryptophan Metabolism | ||||
Reactome | Tryptophan catabolism | ||||
WikiPathways | Tryptophan metabolism | ||||
Metabolism of amino acids and derivatives | |||||
NAD Biosynthesis II (from tryptophan) | |||||
Selenium Micronutrient Network | |||||
References |
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