Target General Infomation
Target ID
T20474
Former ID
TTDR00142
Target Name
DNA topoisomerase
Synonyms
TraE
Target Type
Research
BioChemical Class
DNA topoisomerase
Target Validation
T20474
EC Number
EC 5.99.1.2
Inhibitor 2-Amino-6-(indan-5-ylamino)-3H-pyrimidin-4-one Drug Info [533419]
3-(9-Acridinylamino)-5-(hydroxymethyl)aniline (AHMA) Drug Info [535673]
5-Bromo-6-p-tolylamino-1H-pyrimidine-2,4-dione Drug Info [533419]
6-(3-Bromo-phenylamino)-1H-pyrimidine-2,4-dione Drug Info [533563]
6-(3-Ethyl-phenylamino)-1H-pyrimidine-2,4-dione Drug Info [533563]
6-(3-Iodo-phenylamino)-1H-pyrimidine-2,4-dione Drug Info [533563]
6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione Drug Info [533563]
6-(Naphthalen-2-ylamino)-1H-pyrimidine-2,4-dione Drug Info [533563]
6-Benzylamino-1H-pyrimidine-2,4-dione Drug Info [533419]
6-Benzylamino-5-bromo-1H-pyrimidine-2,4-dione Drug Info [533419]
6-Benzylamino-5-iodo-1H-pyrimidine-2,4-dione Drug Info [533419]
6-p-Tolylamino-1H-pyrimidine-2,4-dione Drug Info [533563]
AHMA Drug Info [535673]
N*4*-Benzyl-6-chloro-pyrimidine-2,4-diamine Drug Info [533419]
TOPOSTATIN Drug Info [526096]
References
Ref 526096J Nat Prod. 2001 Feb;64(2):204-7.Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba.
Ref 533419J Med Chem. 1986 May;29(5):676-81.Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines.
Ref 533563J Med Chem. 1980 Jan;23(1):34-8.Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils.
Ref 535673Crystallization and preliminary X-ray analysis of anti-cancer agent 3-(9-acridinylamino)-5-(hydroxymethyl)aniline complexed with the DNA hexamer d(CGTACG)2. Biochim Biophys Acta. 2003 Jan 3;1625(1):27-9.

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