Target Information
Target General Infomation | |||||
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Target ID |
T20474
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Former ID |
TTDR00142
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Target Name |
DNA topoisomerase
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Synonyms |
TraE
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Target Type |
Research
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BioChemical Class |
DNA topoisomerase
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Target Validation |
T20474
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EC Number |
EC 5.99.1.2
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Inhibitor | 2-Amino-6-(indan-5-ylamino)-3H-pyrimidin-4-one | Drug Info | [533419] | ||
3-(9-Acridinylamino)-5-(hydroxymethyl)aniline (AHMA) | Drug Info | [535673] | |||
5-Bromo-6-p-tolylamino-1H-pyrimidine-2,4-dione | Drug Info | [533419] | |||
6-(3-Bromo-phenylamino)-1H-pyrimidine-2,4-dione | Drug Info | [533563] | |||
6-(3-Ethyl-phenylamino)-1H-pyrimidine-2,4-dione | Drug Info | [533563] | |||
6-(3-Iodo-phenylamino)-1H-pyrimidine-2,4-dione | Drug Info | [533563] | |||
6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione | Drug Info | [533563] | |||
6-(Naphthalen-2-ylamino)-1H-pyrimidine-2,4-dione | Drug Info | [533563] | |||
6-Benzylamino-1H-pyrimidine-2,4-dione | Drug Info | [533419] | |||
6-Benzylamino-5-bromo-1H-pyrimidine-2,4-dione | Drug Info | [533419] | |||
6-Benzylamino-5-iodo-1H-pyrimidine-2,4-dione | Drug Info | [533419] | |||
6-p-Tolylamino-1H-pyrimidine-2,4-dione | Drug Info | [533563] | |||
AHMA | Drug Info | [535673] | |||
N*4*-Benzyl-6-chloro-pyrimidine-2,4-diamine | Drug Info | [533419] | |||
TOPOSTATIN | Drug Info | [526096] | |||
References | |||||
Ref 526096 | J Nat Prod. 2001 Feb;64(2):204-7.Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. | ||||
Ref 533419 | J Med Chem. 1986 May;29(5):676-81.Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. |
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