Target Information
Target General Infomation | |||||
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Target ID |
T42854
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Former ID |
TTDI02338
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Target Name |
Melanoma associated antigen 1
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Gene Name |
MAGEA1
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Synonyms |
Antigen MZ2E; CT1.1; Cancer/testis antigen 1.1; MAGE1 antigen; Melanomaassociated antigen 1; MAGEA1
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Target Type |
Discontinued
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Disease | Melanoma [ICD9: 172; ICD10: C43] | ||||
Function |
May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
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BioChemical Class |
Melanoma associated antigen family
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UniProt ID | |||||
Sequence |
MSLEQRSLHCKPEEALEAQQEALGLVCVQAATSSSSPLVLGTLEEVPTAGSTDPPQSPQG
ASAFPTTINFTRQRQPSEGSSSREEEGPSTSCILESLFRAVITKKVADLVGFLLLKYRAR EPVTKAEMLESVIKNYKHCFPEIFGKASESLQLVFGIDVKEADPTGHSYVLVTCLGLSYD GLLGDNQIMPKTGFLIIVLVMIAMEGGHAPEEEIWEELSVMEVYDGREHSAYGEPRKLLT QDLVQEKYLEYRQVPDSDPARYEFLWGPRALAETSYVKVLEYVIKVSARVRFFFPSLREA ALREEEEGV |
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Drugs and Mode of Action | |||||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
WikiPathways | Notch Signaling Pathway | ||||
References |
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