Target Information

Target General Infomation
Target ID
T78915
Former ID
TTDI01969
Target Name
Tryptophan 5-hydroxylase-1
Gene Name
TPH1
Synonyms
TPH1
Target Type
Clinical Trial
Disease Psychotic disorders [ICD9: 290-299; ICD10: F20-F29]
BioChemical Class
Oxidoreductases acting on paired donors
UniProt ID
P17752
EC Number
EC 1.14.16.4
Sequence
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
Drugs and Mode of Action
Drug(s) AGN-2979 Drug Info Phase 2 Psychotic disorders [526166]
Inhibitor 6-fluorotryptophan Drug Info [533554]
alpha-propyldopacetamide Drug Info [543387]
fenclonine Drug Info [543387]
Modulator AGN-2979 Drug Info [526166]
Pathways
BioCyc Pathway Superpathway of tryptophan utilization
Serotonin and melatonin biosynthesis
KEGG Pathway Tryptophan metabolism
Metabolic pathways
Serotonergic synapse
PANTHER Pathway 5-Hydroxytryptamine biosynthesis
PathWhiz Pathway Tryptophan Metabolism
WikiPathways SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Tryptophan metabolism
Metabolism of amino acids and derivatives
References
Ref 526166Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats. Eur Neuropsychopharmacol. 2001 Oct;11(5):351-7.
Ref 526166Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats. Eur Neuropsychopharmacol. 2001 Oct;11(5):351-7.
Ref 533554(+)-6-fluorotryptophan, an inhibitor of tryptophan hydroxylase: sleep and wakefulness in the rat. Neuropharmacology. 1981 Apr;20(4):335-9.
Ref 543387(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1241).

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