Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0ZI0C
|
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| Former ID |
DIB007781
|
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| Drug Name |
Dersalazine
|
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| Synonyms |
UR-12715; UR-12746
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| Drug Type |
Small molecular drug
|
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| Indication | Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51] | Phase 2 | [1] | ||
| Company |
Grupo Uriach
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C35H31N6NaO4
|
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| Canonical SMILES |
n1(c(nc2c1ccnc2)C)CC1CCN(C(=O)/C=C(\c2ccc(/N=N/c3cc(C(=<br />O)O)c(cc3)O)cc2)/c2ccccc2)CC1
|
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| CAS Number |
CAS 188913-58-8
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Platelet-activating factor receptor | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Staphylococcus aureus infection | |||||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| Leptin Signaling Pathway | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (q) signalling events | |||||
| Interferon gamma signaling | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Small Ligand GPCRs | |||||
| Interferon gamma signaling | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | The intestinal anti-inflammatory effect of dersalazine sodium is related to a down-regulation in IL-17 production in experimental models of rodent colitis. Br J Pharmacol. 2012 February; 165(3): 729-740. | ||||
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