Drug General Information
Drug ID	D0ZE5V
Former ID	DIB010354
Drug Name	FPL-55712
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Terminated	[544540]
Company	Fisons plc
Structure		Download 2D MOL 3D MOL
Formula	C27H29NaO9
Canonical SMILES	c12c(c(ccc1c(=O)cc(o2)C(=O)[O-])OCC(COc1c(c(c(cc1)C(=O)<br />C)O)CCC)O)CCC.[Na+]
CAS Number	CAS 40786-08-1
PubChem Compound ID	23662025
Target and Pathway
Target(s)	Cysteinyl leukotriene receptor 1	Target Info	Modulator	[529534]
	Leukotriene CysLT2 receptor	Target Info	Modulator	[529534]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
	Neuroactive ligand-receptor interaction
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
	IL4 Signaling Pathway
	IL3 Signaling PathwayNetPath_16:IL4 Signaling Pathway
	IL3 Signaling Pathway
Pathway Interaction Database	Endothelinsendothelinpathway:Endothelins
Reactome	Leukotriene receptors
	G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
	GPCR downstream signaling
References
Ref 544540	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000089)
Ref 529534	Effect of the leukotriene receptor antagonists FPL 55712, LY 163443, and MK-571 on the elimination of cysteinyl leukotrienes in the rat. Br J Pharmacol. 1991 Apr;102(4):865-70.

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