Drug Information

Drug General Information
Drug ID
D0Z8HG
Former ID
DAP000354
Drug Name
Vecuronium
Synonyms
Norcuron (TN); (2A,3A,5A,16A,17A)-3,17-diacetoxy-16-(1-methylpiperidinium-1-yl)-2-(piperidin-1-yl)androstane; (2beta,3alpha,5alpha,16beta,17beta)-3,17-diacetoxy-16-(1-methylpiperidinium-1-yl)-2-(piperidin-1-yl)androstane; [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-10,13-dimethyl-16-(1-methylpiperidin-1-ium-1-yl)-2-piperidin-1-yl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
Drug Type
Small molecular drug
Indication Spasms; Pain [ICD9: 338,780; ICD10:R52, G89] Approved [536361], [540619]
Therapeutic Class
Analgesics
Company
Bedford Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C34H57N2O4+
InChI
InChI=1S/C34H57N2O4/c1-23(37)39-31-20-25-12-13-26-27(34(25,4)22-29(31)35-16-8-6-9-17-35)14-15-33(3)28(26)21-30(32(33)40-24(2)38)36(5)18-10-7-11-19-36/h25-32H,6-22H2,1-5H3/q+1/t25-,26+,27-,28-,29-,30-,31-,32-,33-,34-/m0/s1
InChIKey
BGSZAXLLHYERSY-XQIGCQGXSA-N
CAS Number
CAS 50700-72-6
PubChem Compound ID
39765
PubChem Substance ID
9756, 8176218, 14837446, 34705625, 46507656, 50112721, 50621251, 87246434, 92309078, 104332628, 117550021, 123097011, 135065904, 135962408, 137241739, 139157515, 160964634, 164153588, 165698506, 175266821, 175442172, 176484500, 178100828, 179150509, 184664916, 238570034, 252811085
SuperDrug ATC ID
M03AC03
SuperDrug CAS ID
cas=050700726
Target and Pathway
Target(s) Neuronal acetylcholinereceptor subunit alpha-2 Target Info Antagonist [536781], [537286]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Nicotinic acetylcholine receptor signaling pathway
Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 540619(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4002).
Ref 536781Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. Anesth Analg. 2008 Aug;107(2):525-33.
Ref 537286Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52.

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