Drug General Information
Drug ID
D0Z5LU
Former ID
DNC011377
Drug Name
NSC-119913
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531262]
Structure
Download
2D MOL

3D MOL

Formula
C22H18O7
Canonical SMILES
CC1C2C=CC1C(C2C3=C4C=CC(=O)C(=C4OC5=C3C=CC(=C5O)O)O)C(=<br />O)O
InChI
1S/C22H18O7/c1-8-9-2-3-10(8)17(22(27)28)16(9)15-11-4-6-13(23)18(25)20(11)29-21-12(15)5-7-14(24)19(21)26/h2-10,16-17,23,25-26H,1H3,(H,27,28)
InChIKey
BSAMRWOMXJWVCE-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Heat shock protein 70 Target Info Inhibitor [531262]
73-kDa molecular chaperone HSP73 Target Info Inhibitor [531262]
KEGG Pathway Spliceosome
MAPK signaling pathway
Protein processing in endoplasmic reticulum
Endocytosis
Antigen processing and presentation
Estrogen signaling pathway
Legionellosis
Toxoplasmosis
Measles
Influenza A
Epstein-Barr virus infection
NetPath Pathway TCR Signaling Pathway
TSH Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
Parkinson disease
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
C-MYB transcription factor network
Reactome Regulation of HSF1-mediated heat shock response
Attenuation phase
HSF1-dependent transactivation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
CHL1 interactions
mRNA Splicing - Major Pathway
WikiPathways Diurnally Regulated Genes with Circadian Orthologs
MAPK Signaling Pathway
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
GABA synthesis, release, reuptake and degradation
Parkin-Ubiquitin Proteasomal System pathway
Membrane Trafficking
L1CAM interactions
References
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).

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