| Drug General Information |
| Drug ID |
D0Z3JI
|
| Former ID |
DNC002579
|
| Drug Name |
N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C6H14N2S
|
| Canonical SMILES |
CCCCN=C(N)SC
|
| InChI |
1S/C6H14N2S/c1-3-4-5-8-6(7)9-2/h3-5H2,1-2H3,(H2,7,8)
|
| InChIKey |
WLIDQCHXBFDAKG-UHFFFAOYSA-N
|
| PubChem Compound ID |
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| PubChem Substance ID |
|
| Target and Pathway |
| Target(s) |
Nitric-oxide synthase, endothelial |
Target Info |
Inhibitor |
[1]
|
|---|
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BioCyc Pathway
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Citrulline-nitric oxide cycle
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KEGG Pathway
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Arginine and proline metabolism
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Metabolic pathways
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Calcium signaling pathway
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cGMP-PKG signaling pathway
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HIF-1 signaling pathway
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Sphingolipid signaling pathway
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PI3K-Akt signaling pathway
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VEGF signaling pathway
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Platelet activation
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Estrogen signaling pathway
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Oxytocin signaling pathway
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NetPath Pathway
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Wnt Signaling Pathway
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PANTHER Pathway
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Angiogenesis
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Endothelin signaling pathway
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Interleukin signaling pathway
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PI3 kinase pathway
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VEGF signaling pathway
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Pathway Interaction Database
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Plasma membrane estrogen receptor signaling
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Validated transcriptional targets of AP1 family members Fra1 and Fra2
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Angiopoietin receptor Tie2-mediated signaling
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Thromboxane A2 receptor signaling
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SHP2 signaling
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VEGFR1 specific signals
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Signaling events mediated by VEGFR1 and VEGFR2
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PAR1-mediated thrombin signaling events
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Reactome
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ROS production in response to bacteria
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Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
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eNOS activation
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Nitric oxide stimulates guanylate cyclase
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VEGFR2 mediated vascular permeability
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WikiPathways
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ACE Inhibitor Pathway
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EGF/EGFR Signaling Pathway
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Myometrial Relaxation and Contraction Pathways
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JAK/STAT
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Corticotropin-releasing hormone
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AGE/RAGE pathway
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Endothelin Pathways
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Leptin signaling pathway
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Effects of Nitric Oxide
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Metabolism of nitric oxide
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Angiogenesis
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| References |
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |
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