| Drug General Information |
| Drug ID |
D0Z1HQ
|
| Former ID |
DNC001138
|
| Drug Name |
PNU156804
|
| Drug Type |
Small molecular drug
|
| Indication |
Renal transplantation [ICD9: 279.5; ICD10:D89.8]
|
Terminated |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H29N3O6S
|
| Canonical SMILES |
CCCCCCSCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N
|
| InChI |
1S/C16H29N3O6S/c1-2-3-4-5-8-26-10-12(15(23)18-9-14(21)22)19-13(20)7-6-11(17)16(24)25/h11-12H,2-10,17H2,1H3,(H,18,23)(H,19,20)(H,21,22)(H,24,25)/t11-,12-/m0/s1
|
| InChIKey |
HXJDWCWJDCOHDG-RYUDHWBXSA-N
|
| CAS Number |
CAS 24853-32-5
|
| PubChem Compound ID |
|
| PubChem Substance ID |
5817, 585425, 819236, 821129, 823936, 824020, 824024, 826418, 829518, 829659, 830064, 834684, 835651, 836634, 6436227, 8022091, 8028121, 10229013, 10317448, 11538282, 17422866, 22394985, 24398011, 26703322, 26706156, 26736639, 44427844, 46393646, 46393976, 46488157, 50064611, 50130551, 53786802, 57336490, 57580714, 79069274, 85261598, 85261599, 85852805, 87226151, 87544252, 103398048, 103827809, 103993604, 104421164, 124361029, 128126732, 134340373, 134340524, 135052467
|
| Target and Pathway |
| Target(s) |
Tyrosine-protein kinase JAK3 |
Target Info |
Inhibitor |
[2]
|
|---|
|
KEGG Pathway
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Chemokine signaling pathway
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PI3K-Akt signaling pathway
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Signaling pathways regulating pluripotency of stem cells
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Jak-STAT signaling pathway
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Measles
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HTLV-I infection
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Epstein-Barr virus infection
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Viral carcinogenesis
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Primary immunodeficiency
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PANTHER Pathway
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Interleukin signaling pathway
|
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JAK/STAT signaling pathway
|
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PDGF signaling pathway
|
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Pathway Interaction Database
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IL4-mediated signaling events
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CD40/CD40L signaling
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Signaling events mediated by TCPTP
|
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SHP2 signaling
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IL2-mediated signaling events
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IL2 signaling events mediated by PI3K
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IL2 signaling events mediated by STAT5
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Reactome
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GPVI-mediated activation cascade
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Interleukin-7 signaling
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G beta:gamma signalling through PI3Kgamma
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Interleukin-2 signaling
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RAF/MAP kinase cascade
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Interleukin receptor SHC signaling
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WikiPathways
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IL-2 Signaling Pathway
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IL-4 Signaling Pathway
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Interleukin-2 signaling
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Interleukin-7 signaling
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Oncostatin M Signaling Pathway
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IL-9 Signaling Pathway
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IL-7 Signaling Pathway
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Interleukin-3, 5 and GM-CSF signaling
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| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008393) |
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| REF 2 | Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin. Blood. 2002 Jan 15;99(2):680-9. |
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