Drug Information

Drug General Information
Drug ID
D0Z0PB
Former ID
DCL000178
Drug Name
NGD-8243
Drug Type
Small molecular drug
Indication Acute or chronic pain [ICD9: 338,780; ICD10:R52, G89] Discontinued in Phase 2 [548267]
Therapeutic Class
Analgesics
Company
Neurogen Corp
Structure
Download
2D MOL

3D MOL
Formula
C21H12F6N4
Canonical SMILES
C1=CC(=CC=C1C(F)(F)F)NC2=NC=NC3=C2C=CC(=C3)C4=C(C=CN=C4<br />)C(F)(F)F
InChI
1S/C21H12F6N4/c22-20(23,24)13-2-4-14(5-3-13)31-19-15-6-1-12(9-18(15)29-11-30-19)16-10-28-8-7-17(16)21(25,26)27/h1-11H,(H,29,30,31)
InChIKey
LJYSWMNKRHYTHY-UHFFFAOYSA-N
PubChem Compound ID
56603682
PubChem Substance ID
134338853
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Blocker [537396]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 548267Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023970)
Ref 537396Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. Epub 2009 Mar 5.

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