Drug Information

Drug General Information
Drug ID
D0YB7F
Former ID
DIB020458
Drug Name
MT-II
Synonyms
melanotan II; MTII
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538813]
Structure
Download
2D MOL
Formula
C50H69N15O9
InChI
InChI=1S/C50H69N15O9/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,70)(H,64,74)(H,65,69)(H4,52,53,56)/t35-,36-,37-,38+,39-,40-,41-/m0/s1
InChIKey
JDKLPDJLXHXHNV-MFVUMRCOSA-N
PubChem Compound ID
92432
PubChem Substance ID
14890081, 14939041, 16659180, 44423271, 50064256, 50112577, 57335280, 80867774, 93815086, 103481530, 104068740, 104121488, 104407428, 123389854, 134340245, 134343469, 135048952, 135652308, 137274328, 139116892, 142227675, 144240042, 152134073, 152344279, 152344459, 162177756, 162222552, 164828419, 184605715, 187072143, 227296747, 244119246, 249719041, 251915695, 251917045, 252156616, 252351544
Target and Pathway
Target(s) Melanocortin-4 receptor Target Info Agonist [525923]
Melanocortin MC5 receptor Target Info Agonist [535447]
Melanocyte stimulating hormone receptor Target Info Agonist [533012]
Melanocortin-3 receptor Target Info Agonist [525589]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Melanogenesishsa04080:Neuroactive ligand-receptor interaction
Pathway Interaction Database Syndecan-3-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (s) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (s) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 538813(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1323).
Ref 525589Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat. Eur J Pharmacol. 1999 Aug 13;378(3):249-58.
Ref 525923Molecular determinants of ligand binding to the human melanocortin-4 receptor. Biochemistry. 2000 Dec 5;39(48):14900-11.
Ref 533012Design of potent linear alpha-melanotropin 4-10 analogues modified in positions 5 and 10. J Med Chem. 1989 Jan;32(1):174-9.
Ref 535447The role of melanocortins in body weight regulation: opportunities for the treatment of obesity. Eur J Pharmacol. 2002 Apr 12;440(2-3):141-57.

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