| Drug General Information |
| Drug ID |
D0Y8DZ
|
| Former ID |
DNC003897
|
| Drug Name |
4-Ethyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneamine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C7H12N2
|
| Canonical SMILES |
CCC1=CC(=NCC1)N
|
| InChI |
1S/C7H12N2/c1-2-6-3-4-9-7(8)5-6/h5H,2-4H2,1H3,(H2,8,9)
|
| InChIKey |
PZWTXXAVOPPTGW-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Nitric-oxide synthase, endothelial |
Target Info |
Inhibitor |
[1]
|
|---|
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BioCyc Pathway
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Citrulline-nitric oxide cycle
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KEGG Pathway
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Arginine and proline metabolism
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Metabolic pathways
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Calcium signaling pathway
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cGMP-PKG signaling pathway
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HIF-1 signaling pathway
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Sphingolipid signaling pathway
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PI3K-Akt signaling pathway
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VEGF signaling pathway
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Platelet activation
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Estrogen signaling pathway
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Oxytocin signaling pathway
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NetPath Pathway
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Wnt Signaling Pathway
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PANTHER Pathway
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Angiogenesis
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Endothelin signaling pathway
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Interleukin signaling pathway
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PI3 kinase pathway
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VEGF signaling pathway
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Pathway Interaction Database
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Plasma membrane estrogen receptor signaling
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Validated transcriptional targets of AP1 family members Fra1 and Fra2
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Angiopoietin receptor Tie2-mediated signaling
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Thromboxane A2 receptor signaling
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SHP2 signaling
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VEGFR1 specific signals
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Signaling events mediated by VEGFR1 and VEGFR2
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PAR1-mediated thrombin signaling events
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Reactome
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ROS production in response to bacteria
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Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
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eNOS activation
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Nitric oxide stimulates guanylate cyclase
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VEGFR2 mediated vascular permeability
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WikiPathways
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ACE Inhibitor Pathway
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EGF/EGFR Signaling Pathway
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Myometrial Relaxation and Contraction Pathways
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JAK/STAT
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Corticotropin-releasing hormone
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AGE/RAGE pathway
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Endothelin Pathways
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Leptin signaling pathway
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Effects of Nitric Oxide
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Metabolism of nitric oxide
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Angiogenesis
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| References |
| REF 1 | Bioorg Med Chem Lett. 2002 Sep 2;12(17):2291-4.Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines. |
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