Drug Information

Drug General Information
Drug ID
D0Y4YV
Former ID
DIB020931
Drug Name
schisandrin A
Synonyms
(-)-deoxyschisandrin; (-)-dimethylgomisin J
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539814]
Structure
Download
2D MOL
Formula
C24H32O6
InChI
InChI=1S/C24H32O6/c1-13-9-15-11-17(25-3)21(27-5)23(29-7)19(15)20-16(10-14(13)2)12-18(26-4)22(28-6)24(20)30-8/h11-14H,9-10H2,1-8H3/t13-,14+
InChIKey
JEJFTTRHGBKKEI-OKILXGFUSA-N
PubChem Compound ID
155256
PubChem Substance ID
622069, 10252559, 15031010, 17489907, 26725286, 46231260, 57348114, 60811184, 76207842, 88785233, 92710583, 95154777, 103559573, 104440860, 124798645, 126631730, 126658098, 135111772, 135652716, 137238557, 137331352, 143481378, 152099875, 162187702, 163123649, 179342389, 204360448, 228518455, 248186130, 252163660
Target and Pathway
Target(s) Pregnane X receptor Target Info Agonist [527840]
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Pregnane X Receptor pathway
Drug Induction of Bile Acid Pathway
Nuclear Receptors
References
Ref 539814(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2769).
Ref 527840Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. J Pharmacol Exp Ther. 2006 Mar;316(3):1369-77. Epub 2005 Nov 2.

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