Drug Information

Drug General Information
Drug ID
D0Y2ES
Former ID
DIB016539
Drug Name
Bepafant
Synonyms
STY-2108; WEB-2170
Drug Type
Small molecular drug
Indication Septic shock [ICD9: 785.52; ICD10:A41.9] Terminated [541324], [544548]
Company
Boehringer Ingelheim Corp
Structure
Download
2D MOL

3D MOL
Formula
C23H22ClN5O2S
InChI
InChI=1S/C23H22ClN5O2S/c1-13-26-27-19-12-25-21(15-4-2-3-5-17(15)24)20-16-10-14(11-18(16)32-23(20)29(13)19)22(30)28-6-8-31-9-7-28/h2-5,14H,6-12H2,1H3
InChIKey
FWYVRZOREBYLCY-UHFFFAOYSA-N
CAS Number
CAS 114776-28-2
PubChem Compound ID
65923
PubChem Substance ID
8190039, 14907366, 43122661, 50064188, 51735392, 57315829, 76715572, 103345310, 103941567, 103946020, 104335036, 117465118, 127911647, 135024865, 178102699, 179149632, 225145931, 226472055
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Antagonist [531921]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 541324(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6078).
Ref 544548Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000108)
Ref 531921Pharmacologic activity of bepafant (WEB 2170), a new and selective hetrazepinoic antagonist of platelet activating factor. J Pharmacol Exp Ther. 1990 Dec;255(3):962-8.

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