Drug Information

Drug General Information
Drug ID
D0Y0GH
Former ID
DAP000994
Drug Name
Mitomycin
Synonyms
Ametycin; Ametycine; MMC; Mitamycin; Mitomicina; Mitomycine; Mitomycins; Mitomycinum; Mitozytrex; Muamycin; Mutamycin; Mytomycin; Mytozytrex; Mitocin C; Mitomycin C; Mitomycin C from Streptomyces caespitosus; Mitomycinum C; Mitomycyna C; Mitomycyna C [Polish]; Mit-C; Mito-C; Mitocin-C; Mitomicina [INN-Spanish]; Mitomycin (TN); Mitomycin C (JP15); Mitomycin C, Streptomyces caespitosus; Mitomycin-C; Mitomycine [INN-French]; Mitomycinum [INN-Latin]; Muamycin (TN); Mitomycin (USP/INN); Mitomycin [USAN:INN:BAN]; Mitomycin C, Streptomyces caespitosus, Carrier-Free; 7-Amino-9alpha-methoxymitosane
Drug Type
Small molecular drug
Indication Gastrointestinal cancers; Breast cancers [ICD9: 150-159, 174, 175; ICD10:C15-C26, C50] Approved [536361], [542094]
Therapeutic Class
Anticancer Agents
Structure
Download
2D MOL

3D MOL
Formula
C15H18N4O5
InChI
InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
InChIKey
NWIBSHFKIJFRCO-WUDYKRTCSA-N
CAS Number
CAS 50-07-7
PubChem Compound ID
5746
PubChem Substance ID
8906, 87663, 613813, 7847275, 8144500, 8153525, 11120094, 11120582, 11121070, 11121809, 11122289, 11147177, 11363021, 11365583, 11368145, 11371173, 11371174, 11373746, 11376307, 14899962, 14924490, 15249200, 24896554, 24896555, 24896917, 26759169, 26759192, 29224783, 46508353, 47440503, 47440504, 47589205, 48414068, 48416286, 48423722, 49854359, 50064401, 50111457, 53787087, 56310827, 56311910, 56312869, 56312950, 56313687, 56313798, 56313799, 56314173, 56314310, 57260126, 57322926
ChEBI ID
ChEBI:27504
SuperDrug ATC ID
L01DC03
SuperDrug CAS ID
cas=000050077
Target and Pathway
Target(s) DNA Target Info Binder [537608]
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 542094(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7089).
Ref 537608Assessment of cell viability, lipid peroxidation and quantification of DNA fragmentation after the treatment of anticancerous drug mitomycin C and curcumin in cultured human blood lymphocytes. Exp Toxicol Pathol. 2009 Jul 14.

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