Drug Information

Drug General Information
Drug ID
D0XT6W
Former ID
DCL001117
Drug Name
PDX-101
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 2 [533034]
Therapeutic Class
Anticancer Agents
Company
National Cancer Institute (NCI)
Structure
Download
2D MOL

3D MOL
Formula
C15H14N2O4S
Canonical SMILES
C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)C=CC(=O)NO
InChI
1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+
InChIKey
NCNRHFGMJRPRSK-MDZDMXLPSA-N
PubChem Compound ID
6918638
PubChem Substance ID
12015640, 14899204, 17195013, 43530003, 48426953, 56374291, 57371991, 71821512, 79324295, 87226498, 87352001, 96025553, 99436973, 103572083, 104222411, 114788279, 124756987, 125163792, 126639499, 126671543, 126731246, 131480674, 134339486, 134964364, 135195315, 135727448, 136367285, 136368059, 136920289, 137008794, 142692247, 143496443, 144115689, 152234942, 152258138, 152344183, 160646977, 162011830, 162037424, 164041886, 164193975, 164202300, 170497642, 174529326, 175608161, 177748389, 179236375, 186022467, 187051798, 188899535
Target and Pathway
Target(s) Histone deacetylase Target Info Modulator [1572591]
References
Ref 533034A Phase II trial of Belinostat (PXD101) in patients with relapsed or refractory peripheral or cutaneous T-cell lymphoma. Br J Haematol. 2015 Mar;168(6):811-9.
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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