Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0X8VV
|
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| Former ID |
DIB001438
|
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| Drug Name |
Flobufen
|
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| Synonyms |
VUFB-16066; VUFB-17203
|
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| Drug Type |
Small molecular drug
|
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| Indication | Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] | Phase 3 | [1] | ||
| Company |
VUFB
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C17H14F2O3
|
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| Canonical SMILES |
c1(c(ccc(c1)F)c1ccc(C(=O)CC(C(=O)O)C)cc1)F
|
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| CAS Number |
CAS 112344-52-2
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Arachidonate 5-lipoxygenase | Target Info | Modulator | [1] | |
| BioCyc Pathway | Aspirin-triggered lipoxin biosynthesis | ||||
| Resolvin D biosynthesis | |||||
| Leukotriene biosynthesis | |||||
| Lipoxin biosynthesis | |||||
| Aspirin triggered resolvin D biosynthesis | |||||
| Aspirin triggered resolvin E biosynthesis | |||||
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| Serotonergic synapse | |||||
| Ovarian steroidogenesis | |||||
| Toxoplasmosis | |||||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| WikiPathways | Vitamin D Receptor Pathway | ||||
| Arachidonic acid metabolism | |||||
| Eicosanoid Synthesis | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | Pharmacological profile of the novel potent antirheumatic 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid. Arzneimittelforschung. 1997 May;47(5):648-52. | ||||
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