| Drug General Information |
| Drug ID |
D0X8MZ
|
| Former ID |
DIB005689
|
| Drug Name |
Alvameline
|
| Synonyms |
Alvameline maleate; LU-25077; LU-25109; LU-31126; LU-32181; Lu-25109M
|
| Drug Type |
Small molecular drug
|
| Indication |
Alzheimer disease [ICD9: 331; ICD10:G30]
|
Terminated |
[1]
|
|---|
| Company |
H Lundbeck A/S
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C9H15N5
|
| Canonical SMILES |
c1(nn(nn1)CC)C1=CCCN(C1)C
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Muscarinic acetylcholine receptor M3 |
Target Info |
Modulator |
[1]
|
|---|
| Muscarinic acetylcholine receptor M1 |
Target Info |
Modulator |
[1]
|
| Muscarinic acetylcholine receptor M2 |
Target Info |
Modulator |
[1]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Cholinergic synapse
|
|
Regulation of actin cytoskeleton
|
|
Insulin secretion
|
|
Salivary secretion
|
|
Gastric acid secretion
|
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Pancreatic secretionhsa04020:Calcium signaling pathway
|
|
cAMP signaling pathway
|
|
PI3K-Akt signaling pathway
|
|
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
|
|
PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
|
|
PathWhiz Pathway
|
Gastric Acid ProductionPW000564:Muscle/Heart Contraction
|
|
Reactome
|
Muscarinic acetylcholine receptors
|
|
Acetylcholine regulates insulin secretion
|
|
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
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G alpha (i) signalling events
|
|
WikiPathways
|
Monoamine GPCRs
|
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Calcium Regulation in the Cardiac Cell
|
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Regulation of Actin Cytoskeleton
|
|
GPCRs, Class A Rhodopsin-like
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
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Integration of energy metabolism
|
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GPCR ligand binding
|
|
GPCR downstream signaling
|
|
GPCRs, OtherWP58:Monoamine GPCRs
|
|
Secretion of Hydrochloric Acid in Parietal Cells
|
|
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
|
|
GPCRs, Other
|
| References |
| REF 1 | In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro. Psychopharmacology (Berl). 1998 Jun;137(3):233-40. |
|---|
