Drug Information
Drug General Information | |||||
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Drug ID |
D0X8MI
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Former ID |
DIB010051
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Drug Name |
Berupipam
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Synonyms |
NNC-22-0010
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Drug Type |
Small molecular drug
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Indication | Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] | Discontinued in Phase 1 | [1] | ||
Company |
Novo Nordisk A/S
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Structure |
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Download2D MOL |
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Formula |
C19H19BrClNO2
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Canonical SMILES |
c1([C@@H]2c3c(cc(c(c3)O)Cl)CCN(C2)C)c2c(cc(c1)Br)CCO2
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CAS Number |
CAS 150490-85-0
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Dopamine D1 receptor | Target Info | Antagonist | [2] | |
KEGG Pathway | Calcium signaling pathway | ||||
cAMP signaling pathway | |||||
Neuroactive ligand-receptor interaction | |||||
Gap junction | |||||
Dopaminergic synapse | |||||
Parkinson's disease | |||||
Cocaine addiction | |||||
Amphetamine addiction | |||||
Morphine addiction | |||||
Alcoholism | |||||
PANTHER Pathway | Dopamine receptor mediated signaling pathway | ||||
PathWhiz Pathway | Dopamine Activation of Neurological Reward System | ||||
Reactome | Dopamine receptors | ||||
G alpha (s) signalling events | |||||
WikiPathways | Hypothetical Network for Drug Addiction | ||||
Monoamine GPCRs | |||||
GPCRs, Class A Rhodopsin-like | |||||
Genes and (Common) Pathways Underlying Drug Addiction | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
References | |||||
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004006) | ||||
REF 2 | Characterization of benzazepine UDP-glucuronosyl-transferases in laboratory animals and man. Xenobiotica. 1995 Jun;25(6):611-22. | ||||
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