Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0X7ZW
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| Former ID |
DIB018241
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| Drug Name |
[3H]apafant
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| Synonyms |
[3H]WEB 2086
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C22H22ClN5O2S
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| InChI |
InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
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| InChIKey |
JGPJQFOROWSRRS-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7848715, 7980891, 8190013, 12013921, 14808862, 26753288, 43122628, 47670896, 47744969, 48268088, 49993653, 50545460, 53787682, 57315807, 58108390, 85209803, 85789087, 91610602, 103186311, 103915258, 104334937, 117465116, 124891592, 124891593, 124894328, 126683013, 128272031, 134339496, 135024015, 135649947, 135651137, 135698199, 144206979, 144207143, 162023346, 163124927, 164835912, 170466052, 179149528, 184536613, 198957763, 204356799, 223468665, 223653758, 226471804, 241375892, 252156455, 252214738, 252339034
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| Target and Pathway | |||||
| Target(s) | Platelet-activating factor receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Staphylococcus aureus infection | |||||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| Leptin Signaling Pathway | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (q) signalling events | |||||
| Interferon gamma signaling | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Small Ligand GPCRs | |||||
| Interferon gamma signaling | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1859). | ||||
| REF 2 | A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J Immunol Methods. 1995 Oct 26;186(2):225-31. | ||||
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