Drug General Information
Drug ID
D0X7IF
Former ID
DAP000958
Drug Name
L-Carnitine
Synonyms
Bicarnesine; Carnicor; Carniking; Carnilean; Carnitene; Carnitine; Carnitolo; Carnitor; Carnovis; Carrier; Karnitin; Lefcar; Levocarnitina; Levocarnitine; Levocarnitinum; Metina; Levocarnitina [Spanish]; Levocarnitinum [Latin]; Vitamin B T; Vitamin BT; Carniking 50; ST 198; C-1985; Carnitor (TN); DRG-0211; L-Carnitine inner salt; L-carnitine Base; Levocarnitine [USAN:INN]; Carnitine (L-form); Gamma-Trimethyl-beta-hydroxybutyrobetaine; Levocarnitine (JAN/USP/INN); Gamma-Trimethyl-ammonium-beta-hydroxybutirate; L-(-)-Carnitine; L-gamma-trimethyl-beta-hydroxybutyrobetaine; R-(-)-3-hydroxy-4-trimethylaminobutyrate; Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide,inner salt; Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, L-(8CI); (-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate; (-)-Carnitine; (-)-L-Carnitin; (-)-L-Carnitine; (3-Carboxy-2-hydroxypropyl)trimethyl-ammonium hydroxide, inner salt; (3R)-3-hydroxy-4-(trimethylammonio)butanoate; (3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate; (L-3-Carboxy-2-hydroxypropyl)trimethylammonium hydroxide, inner salt; (R)-(3-Carboxy-2-hydroxypropyl)trimethylammonium hydroxide; (R)-(3-Carboxy-2-hydroxypropyl)trimethylammonium hydroxide, inner salt; (R)-3-Hydroxy-4-(trimethylammonio)butyrate; (R)-3-Hydroxy-4-trimethylammoniobutyrate; (R)-Carnitine; (S)-carnitine; 1-CARNITINE; 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, hydroxide, inner salt; 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, (2R)-(9CI); 3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydroxide, inner salt; 3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydroxide, innersalt; 3-carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium
Drug Type
Small molecular drug
Indication Nutritional deficiency [ICD9: 260-269; ICD10:E40-E64] Approved [468010], [536186]
Therapeutic Class
Vitamins
Structure
Download
2D MOL

3D MOL

Formula
C7H15NO3
InChI
InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1
InChIKey
PHIQHXFUZVPYII-ZCFIWIBFSA-N
CAS Number
CAS 541-15-1
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:16347
SuperDrug ATC ID
A16AA01
SuperDrug CAS ID
cas=000541151
Target and Pathway
Target(s) Carnitine O-palmitoyltransferase I Target Info Activator [537609]
KEGG Pathway Fatty acid degradation
Fatty acid metabolism
PPAR signaling pathway
AMPK signaling pathway
Adipocytokine signaling pathway
Glucagon signaling pathway
PathWhiz Pathway Fatty acid Metabolism
Reactome RORA activates gene expression
PPARA activates gene expression
Import of palmitoyl-CoA into the mitochondrial matrix
WikiPathways SIDS Susceptibility Pathways
Mitochondrial LC-Fatty Acid Beta-Oxidation
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock
Fatty Acid Beta Oxidation
AMPK Signaling
References
Ref 468010(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4780).
Ref 536186Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90.
Ref 537609Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion. Endocrinology. 2009 Jul 16.

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