Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0X6AU
|
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| Former ID |
DIB004420
|
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| Drug Name |
FAS-031
|
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| Synonyms |
FASi; FAS inhibitors (cancer); FAS-031; FAS-093; FAS-31; FAS-93; FAS inhibitors (cancer), FASgen/Johns Hopkins; Fatty acid synthase inhibitors (cancer), FASgen/Johns Hopkins; FAS inhibitors (cancer), FASgen/Johns Hopkins/Johnson & Johnson; Fatty acid synthase inhibitors (cancer), FASgen/Johns Hopkins/ Johnson & Johnson
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| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Investigative | [1] | ||
| Company |
Johns Hopkins University
|
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| Target and Pathway | |||||
| Target(s) | Fatty acid synthase | Target Info | Inhibitor | [1] | |
| BioCyc Pathway | Fatty acid biosynthesis initiation | ||||
| Fatty acid elongation -- saturated | |||||
| Palmitate biosynthesis | |||||
| KEGG Pathway | Fatty acid biosynthesis | ||||
| Metabolic pathways | |||||
| Fatty acid metabolism | |||||
| AMPK signaling pathway | |||||
| Insulin signaling pathway | |||||
| Pathway Interaction Database | p73 transcription factor network | ||||
| Validated transcriptional targets of deltaNp63 isoforms | |||||
| PathWhiz Pathway | Fatty Acid Biosynthesis | ||||
| Reactome | ChREBP activates metabolic gene expression | ||||
| Activation of gene expression by SREBF (SREBP) | |||||
| Fatty Acyl-CoA Biosynthesis | |||||
| WikiPathways | Fatty Acid Biosynthesis | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Liver X Receptor Pathway | |||||
| Activation of Gene Expression by SREBP (SREBF) | |||||
| SREBF and miR33 in cholesterol and lipid homeostasis | |||||
| SREBP signalling | |||||
| Metabolism of water-soluble vitamins and cofactors | |||||
| Integration of energy metabolism | |||||
| Fatty acid, triacylglycerol, and ketone body metabolism | |||||
| AMPK Signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2608). | ||||
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