Drug General Information
Drug ID
D0X4ZR
Former ID
DAP000052
Drug Name
Bupropion
Synonyms
Amfebutamon; Amfebutamona; Amfebutamone; Amfebutamonum; Elont; AMFEBUTAMONE HCl; Bupropion Hcl; Bupropion SR; Bupropion hydrocloride; Amfebutamona [INN-Spanish]; Amfebutamonum [INN-Latin]; Bupropion (INN); Bupropion (Old RN); Bupropion (USAN); Bupropion [INN:BAN]; Alpha-(tert-Butylamino)-m-chloropropiophenone; Alpha-(tert-butylamino)-m-chloropropiophenone; (+-)-1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone; (+-)-Bupropion; (-)-2-(tert-Butylamino)-3'-chloropropiophenone; (-)-2-(tert-Butylamino)-3'-chlorpropiophenon; 1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]propan-1-one; 1-Propanone; 2-(Tert-Butylamino)-3'-chloropropiophenone; 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one
Drug Type
Small molecular drug
Indication Smoking cessation [ICD9: 292; ICD10:F17.2] Approved [551871]
Company
GlaxoSmithKline plc
Structure
Download
2D MOL

3D MOL

Formula
C13H18ClNO
InChI
InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3
InChIKey
SNPPWIUOZRMYNY-UHFFFAOYSA-N
CAS Number
CAS 34841-39-9
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:3219
SuperDrug ATC ID
N06AX12
SuperDrug CAS ID
cas=034911552
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Inhibitor [537422]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [537422]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP727:Monoamine Transport
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537422Clinically relevant drug interactions with new generation antidepressants and antipsychotics. Ther Umsch. 2009 Jun;66(6):485-92.

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