Drug Information

Drug General Information
Drug ID
D0X1TN
Former ID
DIB020935
Drug Name
sergliflozin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467826]
Structure
Download
2D MOL
Formula
C23H28O9
InChI
InChI=1S/C23H28O9/c1-3-29-23(27)30-13-18-19(24)20(25)21(26)22(32-18)31-17-7-5-4-6-15(17)12-14-8-10-16(28-2)11-9-14/h4-11,18-22,24-26H,3,12-13H2,1-2H3/t18-,19-,20+,21-,22-/m1/s1
InChIKey
QLXKHBNJTPICNF-QMCAAQAGSA-N
PubChem Compound ID
9824918
PubChem Substance ID
14784051, 15103357, 24127616, 44923056, 47208292, 57373440, 76569246, 103612970, 126680471, 135213572, 137239517, 142631992, 178101308, 198965673, 210024011, 223669781, 223848891, 226922885, 241081397, 243264987
Target and Pathway
Target(s) SLGT2 Target Info Inhibitor [528482]
Sodium/glucose cotransporter 1 Target Info Inhibitor [528482]
KEGG Pathway Carbohydrate digestion and absorption
Bile secretion
Mineral absorption
PathWhiz Pathway Lactose Degradation
Trehalose Degradation
Reactome Hexose transport
Na+-dependent glucose transporters
Inositol transportersR-HSA-189200:Hexose transport
Inositol transporters
WikiPathways NRF2 pathway
Nuclear Receptors Meta-Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP2884:NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Metabolism of carbohydrates
References
Ref 467826(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4587).
Ref 528482Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level. J Pharmacol Exp Ther. 2007 Jan;320(1):323-30. Epub 2006 Oct 18.

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