Drug General Information
Drug ID	D0W7XH
Former ID	DNC002340
Drug Name	DR2313
Drug Type	Small molecular drug
Indication	Permanent and transient stroke [ICD9: 434.91, 435.9; ICD10:G45.9, I61-I63]		Investigative	[536077]
Structure		Download 2D MOL 3D MOL
Formula	C8H10N2OS
Canonical SMILES	CC1=NC(=O)C2=C(N1)CCSC2
InChI	1S/C8H10N2OS/c1-5-9-7-2-3-12-4-6(7)8(11)10-5/h2-4H2,1H3,(H,9,10,11)
InChIKey	HRYKZAKEAVZGJD-UHFFFAOYSA-N
PubChem Compound ID	10219702
PubChem Substance ID	15219719, 22608712, 26759382, 40334200, 47211760, 50112881, 57374403, 77559784, 85788202, 99238636, 99246552, 99444148, 103652092, 104120157, 118845236, 121503098, 123392404, 125346955, 126576933, 126629926, 126734873, 132573658, 134964469, 160829200, 160968747, 162023498, 163093889, 163389609, 163687471, 164831363, 165239256, 170482091, 174555355, 202544456, 206247125, 211786564, 218190634, 223573625, 226746836, 240064958, 248372641, 252156560, 252160010, 252218095
Target and Pathway
Target(s)	Poly [ADP-ribose] polymerase-1	Target Info	Inhibitor	[536077]
KEGG Pathway	Base excision repair
	NF-kappa B signaling pathway
PANTHER Pathway	FAS signaling pathway
Pathway Interaction Database	Integrin-linked kinase signaling
	Caspase Cascade in Apoptosis
	Notch-mediated HES/HEY network
Reactome	Dual Incision in GG-NER
WikiPathways	FAS pathway and Stress induction of HSP regulation
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Nanoparticle triggered regulated necrosis
	Corticotropin-releasing hormone
References
Ref 536077	Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov. 2005 May;4(5):421-40.
Ref 536077	Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov. 2005 May;4(5):421-40.

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