Drug General Information
Drug ID
D0W7RI
Former ID
DIB019061
Drug Name
carbacyclin
Synonyms
carboprostacyclin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539193]
Structure
Download
2D MOL
Formula
C21H34O4
InChI
InChI=1S/C21H34O4/c1-2-3-4-8-17(22)10-11-18-19-13-15(7-5-6-9-21(24)25)12-16(19)14-20(18)23/h7,10-11,16-20,22-23H,2-6,8-9,12-14H2,1H3,(H,24,25)/b11-10+,15-7-/t16-,17-,18+,19-,20+/m0/s1
InChIKey
XZFRIPGNUQRGPI-WLPVIMDJSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Agonist [525673]
Prostaglandin E2 receptor, EP4 subtype Target Info Agonist [534478]
Prostaglandin D2 receptor Target Info Agonist [525673]
Prostaglandin E2 receptor, EP1 subtype Target Info Agonist [525673]
Prostacyclin receptor Target Info Agonist [525673]
Prostaglandin F2-alpha receptor Target Info Agonist [525673]
Prostaglandin E2receptor, EP2 subtype Target Info Agonist [525673]
Prostaglandin E2 receptor EP3 subtype Target Info Agonist [534478]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activationhsa04080:Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancerhsa04080:Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Pathways in cancerhsa04080:Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activationhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04024:cAMP signaling pathway
Pathways in cancerhsa04020:Calcium signaling pathway
cAMP signaling pathway
Regulation of lipolysis in adipocytes
Pathways in cancer
NetPath Pathway FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway PI3 kinase pathway
Pathway Interaction Database Thromboxane A2 receptor signalingtxa2pathway:Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through PGD2 receptor and Prostaglandin D2PW000452:Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptorR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (q) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Vitamin D Receptor Pathway
Endothelin Pathways
Platelet homeostasis
GPCR downstream signaling
GPCRs, OtherWP98:Prostaglandin Synthesis and Regulation
Ovarian Infertility Genes
References
Ref 539193(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1893).
Ref 525673The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93.
Ref 534478Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24.

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