Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0W4ZU
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| Former ID |
DNC012053
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| Drug Name |
KURARINOL
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C26H32O7
|
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| Canonical SMILES |
CC(=C)C(CCC(C)(C)O)CC1=C(C=C(C2=C1OC(CC2=O)C3=C(C=C(C=C<br />3)O)O)OC)O
|
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| InChI |
1S/C26H32O7/c1-14(2)15(8-9-26(3,4)31)10-18-20(29)12-23(32-5)24-21(30)13-22(33-25(18)24)17-7-6-16(27)11-19(17)28/h6-7,11-12,15,22,27-29,31H,1,8-10,13H2,2-5H3/t15-,22+/m1/s1
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| InChIKey |
XMUPAAIHKAIUSU-QRQCRPRQSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | CAMP-specific 3',5'-cyclic phosphodiesterase 4A | Target Info | Inhibitor | [1] | |
| CGMP-specific 3',5'-cyclic phosphodiesterase | Target Info | Inhibitor | [1] | ||
| CGMP-inhibited 3',5'-cyclic phosphodiesterase A | Target Info | Inhibitor | [1] | ||
| CAMP-specific 3',5'-cyclic phosphodiesterase 4B | Target Info | Inhibitor | [1] | ||
| KEGG Pathway | Purine metabolism | ||||
| cAMP signaling pathway | |||||
| Morphine addictionhsa00230:Purine metabolism | |||||
| cGMP-PKG signaling pathwayhsa00230:Purine metabolism | |||||
| cGMP-PKG signaling pathway | |||||
| Morphine addiction | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling PathwayNetPath_17:IL5 Signaling Pathway | ||||
| IL2 Signaling Pathway | |||||
| Reactome | DARPP-32 events | ||||
| G alpha (s) signalling eventsR-HSA-418457:cGMP effectsR-HSA-418457:cGMP effects | |||||
| G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events | |||||
| G alpha (s) signalling events | |||||
| WikiPathways | G Protein Signaling PathwaysWP2005:miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBaseWP35:G Protein Signaling Pathways | |||||
| Myometrial Relaxation and Contraction Pathways | |||||
| Nuclear Receptors Meta-Pathway | |||||
| Opioid Signalling | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6.A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. | ||||
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