Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0W4XY
|
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| Former ID |
DCL000938
|
||||
| Drug Name |
PRX-08066
|
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| Drug Type |
Small molecular drug
|
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| Indication | Pulmonary arterial hypertension [ICD9: 416; ICD10:I27.0, I27.2] | Phase 2 | [1] | ||
| Company |
Predix Pharmaceuticals
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C19H17ClFN5S
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 2B receptor | Target Info | Antagonist | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Serotonergic synapse | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| PANTHER Pathway | 5HT2 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Emerging treatments for pulmonary arterial hypertension. Expert Opin Emerg Drugs. 2006 Nov;11(4):609-19. | ||||
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