Drug General Information
Drug ID
D0W4UQ
Former ID
DNC010329
Drug Name
(Z)-5-Amino-3-(4-methoxybenzylidene)indolin-2-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530673]
Structure
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2D MOL

3D MOL

Formula
C16H14N2O2
Canonical SMILES
COC1=CC=C(C=C1)C=C2C3=C(C=CC(=C3)N)NC2=O
InChI
1S/C16H14N2O2/c1-20-12-5-2-10(3-6-12)8-14-13-9-11(17)4-7-15(13)18-16(14)19/h2-9H,17H2,1H3,(H,18,19)/b14-8-
InChIKey
DYCBCUFDDRQCID-ZSOIEALJSA-N
PubChem Compound ID
Target and Pathway
Target(s) Proto-oncogene tyrosine-protein kinase receptor ret Target Info Inhibitor [530673]
KEGG Pathway Endocytosis
Pathways in cancer
Thyroid cancer
Central carbon metabolism in cancer
Pathway Interaction Database Signaling events regulated by Ret tyrosine kinase
Posttranslational regulation of adherens junction stability and dissassembly
WikiPathways SIDS Susceptibility Pathways
Dopaminergic Neurogenesis
References
Ref 530673Bioorg Med Chem. 2010 Feb 15;18(4):1482-96. Epub 2010 Jan 11.Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors.
Ref 530673Bioorg Med Chem. 2010 Feb 15;18(4):1482-96. Epub 2010 Jan 11.Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors.

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