Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0W3ZN
|
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| Former ID |
DNC004311
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| Drug Name |
PD-169316
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C20H13FN4O2
|
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| InChI |
InChI=1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)
|
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| InChIKey |
BGIYKDUASORTBB-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
5426806, 8152893, 11120186, 11120674, 11121162, 11147269, 14876768, 15274767, 17404964, 24278156, 26753552, 26753553, 26759323, 29215153, 29223798, 48334228, 49655233, 53787724, 53800608, 56311900, 57322412, 72257528, 77337470, 85752747, 85788530, 90341746, 91722163, 99302800, 103181420, 104054749, 104307207, 121361128, 124891645, 125335119, 126671679, 126731456, 127511757, 134341516, 135327844, 135697755, 136048667, 136367835, 137046954, 142476820, 143499114, 144116351, 152133992, 152233483, 152344479, 162011905
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| Target and Pathway | |||||
| Target(s) | mRNA of human 5-lipoxygenase | Target Info | Inhibitor | [2] | |
| BioCyc Pathway | Aspirin-triggered lipoxin biosynthesis | ||||
| Resolvin D biosynthesis | |||||
| Leukotriene biosynthesis | |||||
| Lipoxin biosynthesis | |||||
| Aspirin triggered resolvin D biosynthesis | |||||
| Aspirin triggered resolvin E biosynthesis | |||||
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| Serotonergic synapse | |||||
| Ovarian steroidogenesis | |||||
| Toxoplasmosis | |||||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| WikiPathways | Arachidonic acid metabolism | ||||
| Eicosanoid Synthesis | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6016). | ||||
| REF 2 | 2,4,5- triarylimidazole inhibitors of IL-1 biosynthesis, Bioorg. Med. Chem. Lett. 5(11):1171-1176 (1995). | ||||
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