Drug Information

Drug General Information
Drug ID
D0W2UK
Former ID
DIB020039
Drug Name
IK-862
Synonyms
IK862; IK 862; compound 32
Drug Type
Small molecular drug
Indication Discovery agent Investigative [1]
Structure
Download
2D MOL

3D MOL
Formula
C25H27N3O4
InChI
InChI=1S/C25H27N3O4/c1-16-14-18(21-6-4-5-7-22(21)26-16)15-32-20-10-8-19(9-11-20)25(3)12-13-28(24(25)30)17(2)23(29)27-31/h4-11,14,17,31H,12-13,15H2,1-3H3,(H,27,29)/t17-,25+/m1/s1
InChIKey
YDMIPBHQKFOFQW-NSYGIPOTSA-N
PubChem Compound ID
6914621
PubChem Substance ID
14807699, 17137039, 17192217, 26744284, 43526876, 46394147, 56464963, 75751505, 81062655, 99443616, 103389636, 114781360, 134340933, 135264421, 137220239, 140922015, 141013992, 144220632, 160968230, 231736876, 245111508, 252166880
Target and Pathway
Target(s) ADAM 33 Target Info Inhibitor [1]
ADAM 17 Target Info Inhibitor [1]
KEGG Pathway Notch signaling pathway
Alzheimer's disease
Epithelial cell signaling in Helicobacter pylori infection
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Alzheimer disease-presenilin pathway
Notch signaling pathway
Pathway Interaction Database ErbB4 signaling events
TNF receptor signaling pathway
p75(NTR)-mediated signaling
Reactome Nuclear signaling by ERBB4
Collagen degradation
Regulated proteolysis of p75NTR
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 t(7
M1580_K2555) Translocation Mutant
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
TNF signaling
Growth hormone receptor signaling
WikiPathways Notch Signaling Pathway
Copper homeostasis
Notch Signaling Pathway
Growth hormone receptor signaling
BDNF signaling pathway
Alzheimers Disease
Signalling by NGF
Extrinsic Pathway for Apoptosis
References
REF 1Bioorg Med Chem. 2008 Oct 1;16(19):8781-94. Epub 2008 Aug 29.Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.

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