Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0VZ3D
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| Former ID |
DIB013326
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| Drug Name |
AQ-RA-741
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| Drug Type |
Small molecular drug
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| Indication | Cardiovascular disorder [ICD10:I00-I99] | Terminated | [1], [2] | ||
| Company |
Dr Karl Thomae GmbH
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C27H37N5O2
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| InChI |
InChI=1S/C27H37N5O2/c1-3-30(4-2)17-8-7-10-21-14-18-31(19-15-21)20-25(33)32-24-13-6-5-11-22(24)27(34)29-23-12-9-16-28-26(23)32/h5-6,9,11-13,16,21H,3-4,7-8,10,14-15,17-20H2,1-2H3,(H,29,34)
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| InChIKey |
BCUGCHZRMKTPMU-UHFFFAOYSA-N
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| CAS Number |
CAS 123548-16-3
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
10242493, 12014256, 14907179, 26753266, 29308690, 47510065, 48105189, 57343231, 78254277, 85788187, 91746621, 103223257, 104371738, 126436783, 127496880, 131342474, 135084946, 135698248, 162023254, 162312721, 162781867, 172657834, 179149727, 184538649, 196372351, 204380143, 215779624, 223554803, 224953712, 233158255, 252156418, 252166785, 252325817
|
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| Target and Pathway | |||||
| Target(s) | Muscarinic acetylcholine receptor M2 | Target Info | Modulator | [3] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| PI3K-Akt signaling pathway | |||||
| Cholinergic synapse | |||||
| Regulation of actin cytoskeleton | |||||
| PANTHER Pathway | Alzheimer disease-amyloid secretase pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||||
| PathWhiz Pathway | Muscle/Heart Contraction | ||||
| Reactome | Muscarinic acetylcholine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Monoamine GPCRs | |||||
| Calcium Regulation in the Cardiac Cell | |||||
| Regulation of Actin Cytoskeleton | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8584). | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002261) | ||||
| REF 3 | Pharmacological profile of selective muscarinic receptor antagonists on guinea-pig ileal smooth muscle. Eur J Pharmacol. 1994 Mar 3;253(3):275-81. | ||||
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